Human ASPM participates in spindle organisation, spindle orientation and cytokinesis
نویسندگان
چکیده
منابع مشابه
08-P015 Human ASPM participates in cleavage furrow orientation and cytokinesis
During development of the vertebrate CNS, a precise control of planar orientation of the mitotic spindle of dividing neuroepithelial progenitors regulates the equal partitioning of apical attachment sites. This is necessary to maintain sister cells within the neuroepithelial structure. We have previously demonstrated an essential role for the G-protein regulator LGN in this process. Here we use...
متن کاملCytokinesis and the spindle midzone.
At the end of the cell cycle a cell physically divides into two daughter cells in a process called cytokinesis. Cytokinesis consists of at least four steps: (1) The position of the presumptive cytokinesis furrow is specified. (2) A contractile ring is formed. (3) The contractile ring contracts, resulting in furrow ingression. (4) Cytokinesis completes with sealing of the membranes. The mitotic ...
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Nonsense mutations in the ASPM gene have been most frequently identified among familial microcephaly patients. Depletion of ASPM causes spindle pole unfocusing during mitosis in multiple cell types of Drosophila. However, it remains unknown whether human ASPM has a similar function. Here, using CRISPR-based gene knockout (KO) and RNA interference combined with chemical inhibitors and auxin-indu...
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Correct orientation of cell division is considered an important factor for the achievement of normal brain size, as mutations in genes that affect this process are among the leading causes of microcephaly. Abnormal spindle orientation is associated with reduction of the neuronal progenitor symmetric divisions, premature cell cycle exit, and reduced neurogenesis. This mechanism has been involved...
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Asymmetric cell divisions (ACDs) result in two unequal daughter cells and are a hallmark of stem cells. ACDs can be achieved either by asymmetric partitioning of proteins and organelles or by asymmetric cell fate acquisition due to the microenvironment in which the daughters are placed. Increasing evidence suggests that in the mammalian epidermis, both of these processes occur. During embryonic...
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ژورنال
عنوان ژورنال: BMC Cell Biology
سال: 2010
ISSN: 1471-2121
DOI: 10.1186/1471-2121-11-85